Viewpoints / Position Papers

As a leader in the fight against this disease, the Pancreatic Cancer Action Network provides information and commentary about scientific and medical topics.

Consensus Report Offers Recommendations for Pancreatic Cancer Research Progress

An October 2009 consensus report presents recommendations from the 2007 National Cancer Institute Clinical Trials Planning Meeting on Pancreas Cancer Treatment. The meeting was convened so that scientists, physicians, advocates, industry representatives, and government agencies could discuss ways to integrate current scientific knowledge into better clinical trial designs.

The report outlines specific recommendations in the areas of new drug targets, laboratory models to study pancreatic cancer, future clinical trials, tumor banks (biorepositories), and biomarkers. Click here to read the full summary of the report.

Study Documents Significant Underuse of Surgical Resections

Pancreatectomy, the surgical removal of all or part of the pancreas, offers the best chance of long-term control of all types of pancreatic cancer. However, the use of surgery is significantly underused, even among eligible candidates, according to a published national study.*

Led by Karl Y. Bilimoria, MD, a surgeon at Northwestern University in Chicago, the research team analyzed data on 9,559 patients with “potentially resectable” early stage cancers of the pancreas treated between 1995 and 2004. The goal of the study was to evaluate the use of surgery and to find out why physicians chose not to use it as a treatment option in some case.

Surgery was not utilized as a treatment option in 71 percent of cases: the vast majority of the patients. Of these, close to 20 percent were considered too old, too ill or refused the operation. As many as 38 percent were not offered the surgical option, and no identifiable reason was cited for an additional 14 percent of the patients.

Patients treated at centers with a high average annual volume of pancreatic cancer cases and at academic institutions were more likely to undergo surgery than those at low volume centers and community hospitals. Surgical resections were significantly more likely at National Comprehensive Cancer Network hospitals and National Cancer Institute-designated cancer centers. This was most likely is due to clincians’ greater access to the latest diagnostic and surgical approaches, multidisciplinary support, and resources.

For questions about this study, or to find a high-volume center near you, please contact a PALS Associate at 877-272-6226 or email pals@pancan.org.

*Bilimoria, KY, et. al., National Failure to Operate on Early Stage Pancreatic Cancer, Annals of Surgery 2007;246,2:173-180.

Click here to access PubMed and the full-text of this article.

Grant Recipients Collaborate Recipients of Pancreatic Cancer Action Network research grants collaborate on research study. Watch the video abstract here.

©2009 AGA Institute. All rights reserved. For permission to use, email gastro@gastro.org

Plentz R, Park J, and Rhim AD, et al. Inhibition of y-Secretase Activity Inhibits Tumor Progression in a Mouse Model of Pancreatic Ductal Adenocarcinoma. Gastroenterology. 2009;136: 1741–1749