PanCAN Scientific Summit 2023

September 26 & 27 | Boston

REGISTRATION IS NOW CLOSED

For questions, please contact scientificsummit@pancan.org

Driving Research, Inspiring Hope

PanCAN brings together a robust research community through our Community for Progress. These scientists, clinicians, industry partners, donors and patients are leading the way to improve outcomes and change lives. Together, we are making a difference in the fight against pancreatic cancer.


Join us in Boston for PanCAN Scientific Summit 2023! We are offering an exciting program to our Community for Progress. You’ll have the opportunity to:


  • Meet our new PanCAN research grant recipients
  • Learn more about our top research priorities, including advancing treatment options and early detection strategies for patients
  • Hear from PanCAN’s young investigators as well as senior research grant recipients, engage in discussion and build collaboration
  • Meet patient research advocates, colleagues and industry partners who share a common goal to make a difference in the fight against pancreatic cancer

When the Summit ends, we hope you stay in Boston to attend the American Association for Cancer Research (AACR) Special Conference: Pancreatic Cancer.

Thank you for joining us as we work towards achieving a bold goal: A 5-year pancreatic cancer survival rate of 20% by 2030. Your dedication to this community and your passion for this work make all the difference.


*Attire: Business / Business Casual / Wear Your Purple!

Registration is now closed.
For questions, please contact scientificsummit@pancan.org

Tuesday, September 26, 2023
All Times Eastern

5:30 p.m. — 6:30 p.m.

PanCAN Scientific and Medical Advisory Board Reception (invite only)

Strega Restaurant, Wine Room

6:30 p.m. — 8:30 p.m.

General Reception and Poster Session

Terrace Room, Lower Level

Welcome Remarks
Julie Fleshman, JD, MBA, PanCAN President and CEO

Poster Session
2022 Class of Career Development Awards

The role of PP2A in regulating pancreatic cancer macropinocytosis
Brittany Allen-Petersen, PhD, Purdue University
Grant funded by The Rockhammer Charitable Fund

A novel mechanism of MDSC-mediated stromal and T-cell dysregulation
Jashodeep Datta, MD, University of Miami
Grant funded by an anonymous donor

KRAS G12R metabolic reprogramming alters therapeutic sensitivity
G. Aaron Hobbs, PhD, Medical University of South Carolina
Grant funded in memory of Skip Viragh

Immunobiological factors associated with pancreatic cancer disparities
Janielle Maynard, PhD, Johns Hopkins University of School of Medicine
Grant funded by the Chrysalis Fund at the Ventura County Community Foundation

Neuronal checkpoint signaling in pancreas cancer pain
Jami Saloman, PhD, University of Pittsburgh
Grant funded in memory of Skip Viragh

Exploiting the gut microbiome to improve therapy response in PDAC
Rahul Shinde, PhD, The Wistar Institute
Grant funded by an anonymous donor

Fibrosis-mediated transformation in pancreatic cancer risk factors in vitro
Catherine Whittington, PhD, Worcester Polytechnic Institute

2022 Therapeutic Accelerator Award and Therapeutic Accelerator Collaborative Awards

Clinical update and translational studies for the phase 1/2 trial of VS-6766 + Defactinib and GEM + Nab-P in metastatic PDAC
Louis Denis, MD, and Jonathan Pachter, PhD, Verastem Oncology
Grant supported by 1440 Foundation, the Gail V. Coleman-Kenneth M. Bruntel Research Fund, and Lyda Hill Philanthropies

The RAF/MEK clamp avutometinib as the backbone of therapy for pancreatic cancer: Novel combinations with standard of care chemotherapy, FAK inhibitors, KRAS G12D inhibitors and/or autophagy inhibitors
Kirsten Bryant, PhD, and Channing Der, PhD, University of North Carolina at Chapel Hill
Therapeutic Accelerator Collaborative Award funded in memory of Llewellyn Bixby IV through a gift made by his family
David DeNardo, PhD, Washington University in St. Louis
Jonathan Pachter, PhD, Verastem Oncology

Therapeutic Accelerator Award supported by 1440 Foundation, the Gail V. Coleman-Kenneth M. Bruntel Research Fund, and Lyda Hill Philanthropies


Wednesday, September 27, 2023

7:30 — 8:30 a.m.

Breakfast

Terrace Room, Lower Level

8:30 a.m. — 3:30 p.m.

Scientific Sessions

The Square, Lobby Level

8:30 — 8:35 a.m.

Welcome

Julie Fleshman, JD, MBA
Eileen O’Reilly, MD, Memorial Sloan Kettering Cancer Center
Chair, PanCAN Scientific and Medical Advisory Board

8:35 — 9:05 a.m.

PanCAN State of the Union and Welcome 2023 Class of Grantees

Julie Fleshman, JD, MBA

9:05 — 9:50 a.m.

Early Detection

Session Facilitator: Lynn Matrisian, PhD, MBA, PanCAN Chief Science Officer

9:10 — 9:20 a.m.

Early Detection Initiative updates
Suresh Chari, MD, MD Anderson Cancer Center, Study PI

9:20 — 9:50 a.m.

New models for the early detection of pancreatic cancer: EDI ancillary studies
Wansu Chen, PhD, MS, Kaiser Permanente Southern California Medical Group

9:50 — 10:20 a.m.

Health Data

Session Facilitator: Sudheer Doss, PhD, PanCAN Chief Business Officer

9:55 — 10:20 a.m.

Revolutionizing Pancreatic Cancer Drug Discovery and Development with Multi-Omic Patient Data and Digital Twins – The Promise of the PanCAN and Aitia Partnership
Colin Hill, MS, CEO and Co-Founder, Aitia

10:20 — 10:35 a.m.

Break

10:35 a.m. — 12:15 p.m.

2021 Career Development Awards

Session Facilitators: Julie Fleshman, JD, MBA, Eileen O’Reilly, MD

10:35 — 10:55 a.m.

Hnf1b defines an epigenetic ontology of human pancreatic cancer
Rohit Chandwani, MD, PhD, Weill Cornell Medicine
Grant funded by The Jim & Shirley Young Family Foundation

10:55 — 11:15 a.m.

Metabolic link to immunosuppressive fibroblasts in pancreatic cancer
Ralph Francescone, PhD, Henry Ford Health System
Grant funded in memory of Skip Viragh

11:15 — 11:35 a.m.

Targeting BARD1 in pancreatic ductal adenocarcinoma
Aditi Jain, PhD, Thomas Jefferson University

11:35 — 11:55 a.m.

Dissecting malignant evolution unleashed by p53 inactivation in PDAC
John P. Morris IV, PhD, University of North Carolina at Chapel Hill
Grant funded in memory of Skip Viragh

11:55 — 12:15 p.m.

Developing engineered proteins to enhance adoptive cell therapy of PDA
Shannon Oda, PhD, Seattle Children’s Research Institute
Grant funded by Linda E. Amuso in memory of Susan A. Lombardi

12:15 — 1:00 p.m.

Lunch

Terrace Room, Lower Level

1:05 — 3:20 p.m.

Pancreatic Cancer Treatment Approaches

1:05 — 2:25 p.m.

Translational Research Grants

Session Facilitators: Julie Fleshman, JD, MBA, Eileen O’Reilly, MD

1:10 — 1:35 p.m.

Targeting DDX5/p68 with FL118 as a therapeutic approach for treating pancreatic ductal adenocarcinoma (PDAC)
Fengzhi Li, PhD, Roswell Park Comprehensive Cancer Center
Grant extension funded by Kenneth D. Custance and Gladys C. Custance, honoring the memory of Martha 'Molly' Reed Woodroofe

1:35 — 2:00 p.m.

Immunotherapy for pancreatic cancer by saposin C-based nanovesicles
Xiaoyang Qi, PhD, University of Cincinnati
Grant extension funded by Kenneth D. Custance and Gladys C. Custance, honoring the memory of Martha 'Molly' Reed Woodroofe

2:00 — 2:25 p.m.

Exploiting a metabolic vulnerability created by epigenetic therapy
Susan Bates, MD, Columbia University Medical Center
Grant extension funded by Kenneth D. Custance and Gladys C. Custance, honoring the memory of Martha 'Molly' Reed Woodroofe

2:25 — 3:20 p.m.

Precision Medicine Targeted Grant and Therapeutic Accelerator Award

Session Facilitator: Lynn Matrisian, PhD, MBA

2:30 — 2:55 p.m.

Multiplex tissue-based assays and analytical tools for pancreatic cancer
Precision Medicine Targeted Grant
Gregory Beatty, MD, PhD, University of Pennsylvania
2022 grant extension funded by Leslie Gaynor in memory of Phyllis Bolotin

2:55 — 3:20 p.m.

TBD
2023 Therapeutic Accelerator Award
Grant supported in memory of Skip Viragh

3:20 — 3:30 p.m.

Closing Remarks

Eileen O’Reilly, MD, Julie Fleshman, JD, MBA

3:30 p.m. — 4:30 p.m.

Coffee Social/Networking Hour

Library, Lobby Level

LOCATION

Boston Park Plaza Hotel

50 Park Plaza, Boston, MA 02116


PARKING

Attendees wishing to park at the hotel should utilize valet parking and inform the attendant that they are part of the Pancreatic Cancer Action Network group. PanCAN will cover the cost of valet parking. The valet parking entrance is located at 34 Columbus Avenue, Boston, MA 02116.


presenter image

Suresh Chari, MD

MD Anderson Cancer Center

Affiliation: Early Detection Initiative, Study PI

Topic: Early Detection Initiative updates and the REGARD ancillary studies

presenter image

Wansu Chen, PhD, MS

Kaiser Permanente Southern California Medical Group

Affiliation: Early Detection Initiative

Topic: New models for the early detection of pancreatic cancer: EDI ancillary studies

presenter image

Colin Hill, MS

Aitia

Affiliation: Health Data

Topic: Revolutionizing Pancreatic Cancer Drug Discovery and Development with Multi-Omic Patient Data and Digital Twins – The Promise of the PanCAN and Aitia Partnership

presenter image

Rohit Chandwani, MD, PhD

Weill Cornell Medicine

Grant: 2021 Pancreatic Cancer Action Network Career Development Award, funded by The Jim & Shirley Young Family Foundation

Topic: Hnf1b defines an epigenetic ontology of human pancreatic cancer

presenter image

Ralph Francescone, PhD

Henry Ford Health System

Grant: 2021 Pancreatic Cancer Action Network Career Development Award, funded in memory of Skip Viragh

Topic: Metabolic link to immunosuppressive fibroblasts in pancreatic cancer

presenter image

Aditi Jain, PhD

Thomas Jefferson University

Grant: 2021 Pancreatic Cancer Action Network Career Development Award

Topic: Targeting BARD1 in pancreatic ductal adenocarcinoma

presenter image

John P. Morris IV, PhD

University of North Carolina at Chapel Hill

Grant: 2021 Pancreatic Cancer Action Network Career Development Award, funded in memory of Skip Viragh

Topic: Dissecting malignant evolution unleashed by p53 inactivation in PDAC

presenter image

Shannon Oda, PhD

Seattle Children’s Research Institute

Grant: 2021 Pancreatic Cancer Action Network Career Development Award, funded by Linda E. Amuso in memory of Susan A. Lombardi

Topic: Developing engineered proteins to enhance adoptive cell therapy of PDA

presenter image

Fengzhi Li, PhD

Roswell Park Cancer Institute

Grant: 2020 Pancreatic Cancer Action Network Translational Research Grant, extension funded by Kenneth D. Custance and Gladys C. Custance, honoring the memory of Martha 'Molly' Reed Woodroofe

Topic: Targeting DDX5/p68 with FL118 as a therapeutic approach for treating pancreatic ductal adenocarcinoma (PDAC)

presenter image

Xiaoyang Qi, PhD

University of Cincinnati

Grant: 2020 Pancreatic Cancer Action Network Translational Research Grant, extension funded by Kenneth D. Custance and Gladys C. Custance, honoring the memory of Martha 'Molly' Reed Woodroofe

Topic: Immunotherapy of pancreatic cancer by saposin c-based nanovesicles

presenter image

Susan Bates, MD

Columbia University Medical Center

Grant: 2020 Pancreatic Cancer Action Network Translational Research Grant, extension funded by Kenneth D. Custance and Gladys C. Custance, honoring the memory of Martha 'Molly' Reed Woodroofe

Topic: Exploiting a metabolic vulnerability created by epigenetic therapy

presenter image

Gregory Beatty, MD, PhD

University of Pennsylvania

Grant: 2017 Pancreatic Cancer Action Network Precision Medicine Targeted Grant, 2022 Grant Extension funded by Leslie Gaynor in memory of Phyllis Bolotin

Topic: Multiplex tissue-based assays and analytical tools for pancreatic cancer

presenter image

Thomas Heineman, MD, PhD

Oncolytics Biotech, Inc.

Grant: 2023 Pancreatic Cancer Action Network Therapeutic Accelerator Award, supported in memory of Skip Viragh

Topic: Pelareorep + mFOLFIRINOX +/- atezolizumab for the treatment of 1L mPDAC

Andy Aguirre, MD, PhD
Dana-Farber Cancer Institute
Grantee
Andrew_Aguirre@dfci.harvard.edu

Sharon Alincastre
Novocure
salincastre@novocure.com

Brittany Allen-Petersen, PhD
Purdue University
Grantee
ballenpe@purdue.edu

Basil Bakir, MD, PhD
Columbia University
Grantee
bb3041@cumc.columbia.edu

Dafna Bar-Sagi, PhD
NYU Langone Health
PanCAN Scientific and Medical Advisory Board
Dafna.Bar-Sagi@nyulangone.org

Susan Bates, MD
Columbia University
Grantee
seb2227@cumc.columbia.edu

Gregory Beatty, MD, PhD
University of Pennsylvania
Grantee, PanCAN Scientific and Medical Advisory Board, Precision Promise
gregory.beatty@pennmedicine.upenn.edu

Jordan Berlin, MD
Vanderbilt University Medical Center
PanCAN Scientific and Medical Advisory Board
jordan.berlin@vumc.org

Jonathan Brody, PhD
Oregon Health & Science University
PanCAN Scientific and Medical Advisory Board
brodyj@ohsu.edu

Kirsten Bryant, PhD
University of North Carolina at Chapel Hill
Grantee
bryantkl@email.unc.edu

Ewa Carrier, MD
FibroGen
ecarrier@fibrogen.com

Rohit Chandwani, MD, PhD
Weill Cornell Medicine
Grantee
roc9045@med.cornell.edu

Suresh Chari, MD
MD Anderson Cancer Center
Grantee, PanCAN Scientific and Medical Advisory Board, PanCAN Early Detection Initiative
stchari@mdanderson.org

Yuan Chen, PhD
UC San Diego
Grantee
yuc020@health.ucsd.edu

Wansu Chen, PhD
Kaiser Permanente Southern California
Grantee, PanCAN Scientific and Medical Advisory Board, PanCAN Early Detection Initiative
wansu.chen@kp.org

Gabi Chiorean, MD
University of Washington/Fred Hutchinson Cancer Center
PanCAN Scientific and Medical Advisory Board, Precision Promise
gchiorea@outlook.com

Sheena Clift, PhD
Verastem Oncology
sclift@verastem.com

Guillaume Cognet, PhD
University of Chicago
Grantee cognetg@uchicago.edu

Howard Crawford, PhD
Henry Ford Health
PanCAN Scientific and Medical Advisory Board
hcrawfo1@hfhs.org

Jashodeep Datta, MD
University of Miami
Grantee, Precision Promise
jash.datta@med.miami.edu

Louis Denis, MD
Verastem Oncology
Grantee
LDenis@Verastem.com

Channing Der, PhD
University of North Carolina at Chapel Hill
Grantee, PanCAN Scientific and Medical Advisory Board Emeritus
cjder@med.unc.edu

Luis Francisco Diaz
OHSU Knight Cancer Institute
PanCAN Travel Scholar
diazlui@ohsu.edu

Julien Dilly, MSc
Dana-Farber Cancer Institute
Grantee
Julien_Dilly@DFCI.HARVARD.EDU

Efrat Dotan, MD
Fox Chase Cancer Center
PanCAN Scientific and Medical Advisory Board
efrat.dotan@fccc.edu

Stephanie Dougan, PhD
Dana-Farber Cancer Institute
Grantee, Precision Promise
stephanie_dougan@dfci.harvard.edu

José Enriquez
MD Anderson Cancer Center
PanCAN Travel Scholar
JSEnriquez@mdanderson.org

Ralph Francescone, PhD
Henry Ford Health
Grantee
rfrance3@hfhs.org

Will Freed-Pastor, MD, PhD
Dana-Farber Cancer Institute
Grantee
William_Freed-Pastor@DFCI.HARVARD.EDU

Tamer Garawin, MD
Ipsen
tamer.garawin@ipsen.com

Arjun Gupta, MD
University of Minnesota
Grantee
guptaarjun90@gmail.com

Tom Heineman, MD, PhD
Oncolytics Biotech
Grantee
theineman@oncolytics.ca

Andrew Hendifar, MD, MPH
Cedars-Sinai
PanCAN Scientific and Medical Advisory Board, Precision Promise
andrew.hendifar@cshs.org

Joseph Herman, MD, MSc
Northwell Health Cancer Institute
PanCAN Scientific and Medical Advisory Board
jherman1@northwell.edu

Manuel Hidalgo, MD, PhD
Weill Cornell Medicine
PanCAN Scientific and Medical Advisory Board, Precision Promise
Mah4006@med.cornell.edu

Colin Hill
Aitia
Colin@aitiabio.com

Sunil Hingorani, MD, PhD
University of Nebraska Medical Center
Grantee, PanCAN Scientific and Medical Advisory Board, Precision Promise
shingorani@unmc.edu

Aaron Hobbs, PhD
Medical University of South Carolina
Grantee
hobbsg@musc.edu

Tony Hollingsworth, PhD
University of Nebraska Medical Center
PanCAN Scientific and Medical Advisory Board
mahollin@unmc.edu

Peter Hosein, MD
University of Miami
PanCAN Scientific and Medical Advisory Board
phosein@miami.edu

Will Hwang, MD, PhD
Massachusetts General Hospital
Grantee
WHWANG1@mgh.harvard.edu

Aditi Jain, PhD
Thomas Jefferson University
Grantee
Aditi.Jain@jefferson.edu

Avinash Kambadakone-Ramesh, MD, MBBS
Massachusetts General Hospital
PanCAN Early Detection Initiative
AKAMBADAKONE@mgh.harvard.edu

Alison Klein, PhD
Johns Hopkins University
PanCAN Scientific and Medical Advisory Board
aklein1@jhmi.edu

Paul Kurywchak, PhD
Skipper Bio Med
Special Guest
paul@skipperbiomed.com

Ashley Laursen, PhD
Ipsen
ashley.laursen@ipsen.com

Andrew Lee, PharmD
AstraZeneca
andrew.lee4291@gmail.com

Fengzhi Li, PhD
Roswell Park Comprehensive Cancer Center
Grantee
fengzhi.li@roswellpark.org

Andrew Lowy, MD
UC San Diego
PanCAN Scientific and Medical Advisory Board, Precision Promise
Alowy@health.ucsd.edu

Chris Macdonald, PhD
Pancreatic Cancer UK
PanCAN Scientific Collaborator
Chris.Macdonald@pancreaticcancer.org.uk

Sanjana Mahapatra, PhD
Skipper Bio Med
Special Guest
sanjana@skipperbiomed.com

Anirban Maitra, MBBS
MD Anderson Cancer Center
PanCAN Early Detection Initiative, PanCAN Scientific and Medical Advisory Board Emeritus
amaitra@mdanderson.org

Mokenge Malafa, MD
Moffitt Cancer Center
PanCAN Scientific and Medical Advisory Board Emeritus
mokenge.malafa@moffitt.org

Meg Mandelson, PhD, MPH
Benaroya Research Institute
PanCAN Scientific and Medical Advisory Board Emeritus
mmandelson@benaroyaresearch.org

Ronald Matteotti, MD
Bristol Myers Squibb
ronald.matteotti@bms.com

Nipun Merchant, MD
University of Miami
PanCAN Scientific and Medical Advisory Board, Precision Promise
nmerchant@miami.edu

Janielle Maynard, PhD
Johns Hopkins University
Grantee
maynard@jhmi.edu

Simon Miller, MSc
FibroGen
smiller@fibrogen.com

Christine Mormont, PhD
Novocure
cmormont@novocure.com

John Morris IV, PhD
University of North Carolina at Chapel Hill
Grantee
jpmiv@email.unc.edu

Nick Nissen, MD
Cedars-Sinai
PanCAN Scientific and Medical Advisory Board
nicholas.nissen@cshs.org

Marcus Noel, MD
Georgetown Lombardi Comprehensive Cancer Center
PanCAN Scientific and Medical Advisory Board
Marcus.S.Noel@gunet.georgetown.edu

Shannon Oda, PhD
University of Washington, Seattle Children's Research Institute
Grantee
Shannon.Oda@seattlechildrens.org

Kenneth Olive, PhD
Columbia University
Grantee
kpo2104@cumc.columbia.edu

Eileen O'Reilly, MD
Memorial Sloan Kettering Cancer Center
PanCAN Scientific and Medical Advisory Board, Precision Promise
oreillye@mskcc.org

Jon Pachter, PhD
Verastem Oncology
Grantee
jpachter@verastem.com

Shubham Pant, MD
MD Anderson Cancer Center
PanCAN Scientific and Medical Advisory Board, Precision Promise
SPant@mdanderson.org

Marina Pasca di Magliano, PhD
University of Michigan
Grantee, PanCAN Scientific and Medical Advisory Board
marinapa@umich.edu

Krushna Patra, PhD
University of Cincinnati
Grantee
patraka@ucmail.uc.edu

Vince Picozzi, MD
Virginia Mason
PanCAN Scientific and Medical Advisory Board, Precision Promise
vincent.picozzi@commonspirit.org

Michael Pishvaian, MD, PhD
Johns Hopkins University
PanCAN Scientific and Medical Advisory Board
mpishva1@jh.edu

Xiaoyang Qi, PhD
University of Cincinnati
Grantee
xiaoyang.qi@uc.edu

Mustafa Raoof, MD, MSc
City of Hope Comprehensive Cancer Center
Grantee
mraoof@coh.org

Nicolette Rodriguez, MD, MPH
Dana-Farber Cancer Institute
Grantee
njrodriguez@bwh.harvard.edu

Victoire Ruffino, PhD
Institut Curie
Grantee
victoire.ruffino@curie.fr

Maryam Safari, PhD
Columbia University
Special Guest
ms5244@cumc.columbia.edu

Jami Saloman, PhD
University of Pittsburgh
Grantee
jls354@pitt.edu

Rosie Sears, PhD
Oregon Health & Science University
PanCAN Scientific and Medical Advisory Board
searsr@ohsu.edu

Melissa Shackelford, MSc, MPH
Novocure
mshackelford@novocure.com

Sandra Shaw
Mirati Therapeutics
shaws@mirati.com

Rahul Shinde, PhD
The Wistar Institute
Grantee
rshinde@wistar.org

Dustin Srinivas, PhD
Skipper Bio Med
Special Guest
dustin@skipperbiomed.com

Shravya Srinivas Rao, MD, MBBS
Massachusetts General Hospital
PanCAN Early Detection Initiative
ssrinivasrao@mgh.harvard.edu

Sapna Syngal, MD, MPH
Dana-Farber Cancer Institute
Grantee, PanCAN Scientific and Medical Advisory Board
sapna_syngal@dfci.harvard.edu

Margaret Tempero, MD
UC San Francisco
PanCAN Scientific and Medical Advisory Board, Precision Promise
Margaret.tempero@ucsf.edu

Chinedu Ukaegbu, MBBS, MPH
Dana-Farber Cancer Institute
Special Guest
chinedu_ukaegbu@dfci.harvard.edu

Colin Weekes, MD, PhD
Massachusetts General Hospital
PanCAN Scientific and Medical Advisory Board
cdweekes@mgh.harvard.edu

Catherine Whittington, PhD
Worcester Polytechnic Institute
Grantee
cfwhittington@wpi.edu

Jen Jen Yeh, MD
University of North Carolina at Chapel Hill
PanCAN Scientific and Medical Advisory Board
jen_jen_yeh@med.unc.edu
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