PanCAN Scientific Summit 2023
September 26 & 27 | Boston
REGISTRATION IS NOW CLOSED
For questions, please contact scientificsummit@pancan.org
Driving Research, Inspiring Hope
PanCAN brings together a robust research community through our Community for Progress. These scientists, clinicians, industry partners, donors and patients are leading the way to improve outcomes and change lives. Together, we are making a difference in the fight against pancreatic cancer.
Join us in Boston for PanCAN Scientific Summit 2023! We are offering an exciting program to our Community for Progress. You’ll have the opportunity to:
- Meet our new PanCAN research grant recipients
- Learn more about our top research priorities, including advancing treatment options and early detection strategies for patients
- Hear from PanCAN’s young investigators as well as senior research grant recipients, engage in discussion and build collaboration
- Meet patient research advocates, colleagues and industry partners who share a common goal to make a difference in the fight against pancreatic cancer
When the Summit ends, we hope you stay in Boston to attend the American Association for Cancer Research (AACR) Special Conference: Pancreatic Cancer.
Thank you for joining us as we work towards achieving a bold goal: A 5-year pancreatic cancer survival rate of 20% by 2030. Your dedication to this community and your passion for this work make all the difference.
*Attire: Business / Business Casual / Wear Your Purple!
Registration is now closed.
For questions, please contact scientificsummit@pancan.org
Tuesday, September 26, 2023
All Times Eastern
5:30 p.m. — 6:30 p.m.
PanCAN Scientific and Medical Advisory Board Reception (invite only)
Strega Restaurant, Wine Room
6:30 p.m. — 8:30 p.m.
General Reception and Poster Session
Terrace Room, Lower Level
Welcome Remarks
Julie Fleshman, JD, MBA, PanCAN President and CEO
Poster Session
2022 Class of Career Development Awards
The role of PP2A in regulating pancreatic cancer macropinocytosis
Brittany Allen-Petersen, PhD, Purdue University
Grant funded by The Rockhammer Charitable Fund
A novel mechanism of MDSC-mediated stromal and T-cell dysregulation
Jashodeep Datta, MD, University of Miami
Grant funded by an anonymous donor
KRAS G12R metabolic reprogramming alters therapeutic sensitivity
G. Aaron Hobbs, PhD, Medical University of South Carolina
Grant funded in memory of Skip Viragh
Immunobiological factors associated with pancreatic cancer disparities
Janielle Maynard, PhD, Johns Hopkins University of School of Medicine
Grant funded by the Chrysalis Fund at the Ventura County Community Foundation
Neuronal checkpoint signaling in pancreas cancer pain
Jami Saloman, PhD, University of Pittsburgh
Grant funded in memory of Skip Viragh
Exploiting the gut microbiome to improve therapy response in PDAC
Rahul Shinde, PhD, The Wistar Institute
Grant funded by an anonymous donor
Fibrosis-mediated transformation in pancreatic cancer risk factors in vitro
Catherine Whittington, PhD, Worcester Polytechnic Institute
2022 Therapeutic Accelerator Award and Therapeutic Accelerator Collaborative Awards
Clinical update and translational studies for the phase 1/2 trial of VS-6766 + Defactinib and GEM + Nab-P in metastatic PDAC
Louis Denis, MD, and Jonathan Pachter, PhD, Verastem Oncology
Grant supported by 1440 Foundation, the Gail V. Coleman-Kenneth M. Bruntel Research Fund, and Lyda Hill Philanthropies
The RAF/MEK clamp avutometinib as the backbone of therapy for pancreatic cancer: Novel combinations with standard of care chemotherapy, FAK inhibitors, KRAS G12D inhibitors and/or autophagy inhibitors
Kirsten Bryant, PhD, and Channing Der, PhD, University of North Carolina at Chapel Hill
Therapeutic Accelerator Collaborative Award funded in memory of Llewellyn Bixby IV through a gift made by his family
David DeNardo, PhD, Washington University in St. Louis
Jonathan Pachter, PhD, Verastem Oncology
Therapeutic Accelerator Award supported by 1440 Foundation, the Gail V. Coleman-Kenneth M. Bruntel Research Fund, and Lyda Hill Philanthropies
Wednesday, September 27, 2023
7:30 — 8:30 a.m.
Breakfast
Terrace Room, Lower Level
8:30 a.m. — 3:30 p.m.
Scientific Sessions
The Square, Lobby Level
8:30 — 8:35 a.m.
Welcome
Julie Fleshman, JD, MBA
Eileen O’Reilly, MD, Memorial Sloan Kettering Cancer Center
Chair, PanCAN Scientific and Medical Advisory Board
8:35 — 9:05 a.m.
PanCAN State of the Union and Welcome 2023 Class of Grantees
Julie Fleshman, JD, MBA
9:05 — 9:50 a.m.
Early Detection
Session Facilitator: Lynn Matrisian, PhD, MBA, PanCAN Chief Science Officer
Early Detection Initiative updates
Suresh Chari, MD, MD Anderson Cancer Center, Study PI
New models for the early detection of pancreatic cancer: EDI ancillary studies
Wansu Chen, PhD, MS, Kaiser Permanente Southern California Medical Group
9:50 — 10:20 a.m.
Health Data
Session Facilitator: Sudheer Doss, PhD, PanCAN Chief Business Officer
Revolutionizing Pancreatic Cancer Drug Discovery and Development with Multi-Omic Patient Data and Digital Twins – The Promise of the PanCAN and Aitia Partnership
Colin Hill, MS, CEO and Co-Founder, Aitia
10:20 — 10:35 a.m.
Break
10:35 a.m. — 12:15 p.m.
2021 Career Development Awards
Session Facilitators: Julie Fleshman, JD, MBA, Eileen O’Reilly, MD
Hnf1b defines an epigenetic ontology of human pancreatic cancer
Rohit Chandwani, MD, PhD, Weill Cornell Medicine
Grant funded by The Jim & Shirley Young Family Foundation
Metabolic link to immunosuppressive fibroblasts in pancreatic cancer
Ralph Francescone, PhD, Henry Ford Health System
Grant funded in memory of Skip Viragh
Targeting BARD1 in pancreatic ductal adenocarcinoma
Aditi Jain, PhD, Thomas Jefferson University
Dissecting malignant evolution unleashed by p53 inactivation in PDAC
John P. Morris IV, PhD, University of North Carolina at Chapel Hill
Grant funded in memory of Skip Viragh
Developing engineered proteins to enhance adoptive cell therapy of PDA
Shannon Oda, PhD, Seattle Children’s Research Institute
Grant funded by Linda E. Amuso in memory of Susan A. Lombardi
12:15 — 1:00 p.m.
Lunch
Terrace Room, Lower Level
1:05 — 3:20 p.m.
Pancreatic Cancer Treatment Approaches
1:05 — 2:25 p.m.
Translational Research Grants
Session Facilitators: Julie Fleshman, JD, MBA, Eileen O’Reilly, MD
Targeting DDX5/p68 with FL118 as a therapeutic approach for treating pancreatic ductal adenocarcinoma (PDAC)
Fengzhi Li, PhD, Roswell Park Comprehensive Cancer Center
Grant extension funded by Kenneth D. Custance and Gladys C. Custance, honoring the memory of Martha 'Molly' Reed Woodroofe
Immunotherapy for pancreatic cancer by saposin C-based nanovesicles
Xiaoyang Qi, PhD, University of Cincinnati
Grant extension funded by Kenneth D. Custance and Gladys C. Custance, honoring the memory of Martha 'Molly' Reed Woodroofe
Exploiting a metabolic vulnerability created by epigenetic therapy
Susan Bates, MD, Columbia University Medical Center
Grant extension funded by Kenneth D. Custance and Gladys C. Custance, honoring the memory of Martha 'Molly' Reed Woodroofe
2:25 — 3:20 p.m.
Precision Medicine Targeted Grant and Therapeutic Accelerator Award
Session Facilitator: Lynn Matrisian, PhD, MBA
Multiplex tissue-based assays and analytical tools for pancreatic cancer
Precision Medicine Targeted Grant
Gregory Beatty, MD, PhD, University of Pennsylvania
2022 grant extension funded by Leslie Gaynor in memory of Phyllis Bolotin
TBD
2023 Therapeutic Accelerator Award
Grant supported in memory of Skip Viragh
3:20 — 3:30 p.m.
Closing Remarks
Eileen O’Reilly, MD, Julie Fleshman, JD, MBA
3:30 p.m. — 4:30 p.m.
Coffee Social/Networking Hour
Library, Lobby Level
LOCATION
50 Park Plaza, Boston, MA 02116
PARKING
Attendees wishing to park at the hotel should utilize valet parking and inform the attendant that they are part of the Pancreatic Cancer Action Network group. PanCAN will cover the cost of valet parking. The valet parking entrance is located at 34 Columbus Avenue, Boston, MA 02116.
Suresh Chari, MD
MD Anderson Cancer Center
Affiliation: Early Detection Initiative, Study PI
Topic: Early Detection Initiative updates and the REGARD ancillary studies
Wansu Chen, PhD, MS
Kaiser Permanente Southern California Medical Group
Affiliation: Early Detection Initiative
Topic: New models for the early detection of pancreatic cancer: EDI ancillary studies
Colin Hill, MS
Aitia
Affiliation: Health Data
Topic: Revolutionizing Pancreatic Cancer Drug Discovery and Development with Multi-Omic Patient Data and Digital Twins – The Promise of the PanCAN and Aitia Partnership
Rohit Chandwani, MD, PhD
Weill Cornell Medicine
Grant: 2021 Pancreatic Cancer Action Network Career Development Award, funded by The Jim & Shirley Young Family Foundation
Topic: Hnf1b defines an epigenetic ontology of human pancreatic cancer
Ralph Francescone, PhD
Henry Ford Health System
Grant: 2021 Pancreatic Cancer Action Network Career Development Award, funded in memory of Skip Viragh
Topic: Metabolic link to immunosuppressive fibroblasts in pancreatic cancer
Aditi Jain, PhD
Thomas Jefferson University
Grant: 2021 Pancreatic Cancer Action Network Career Development Award
Topic: Targeting BARD1 in pancreatic ductal adenocarcinoma
John P. Morris IV, PhD
University of North Carolina at Chapel Hill
Grant: 2021 Pancreatic Cancer Action Network Career Development Award, funded in memory of Skip Viragh
Topic: Dissecting malignant evolution unleashed by p53 inactivation in PDAC
Shannon Oda, PhD
Seattle Children’s Research Institute
Grant: 2021 Pancreatic Cancer Action Network Career Development Award, funded by Linda E. Amuso in memory of Susan A. Lombardi
Topic: Developing engineered proteins to enhance adoptive cell therapy of PDA
Fengzhi Li, PhD
Roswell Park Cancer Institute
Grant: 2020 Pancreatic Cancer Action Network Translational Research Grant, extension funded by Kenneth D. Custance and Gladys C. Custance, honoring the memory of Martha 'Molly' Reed Woodroofe
Topic: Targeting DDX5/p68 with FL118 as a therapeutic approach for treating pancreatic ductal adenocarcinoma (PDAC)
Xiaoyang Qi, PhD
University of Cincinnati
Grant: 2020 Pancreatic Cancer Action Network Translational Research Grant, extension funded by Kenneth D. Custance and Gladys C. Custance, honoring the memory of Martha 'Molly' Reed Woodroofe
Topic: Immunotherapy of pancreatic cancer by saposin c-based nanovesicles
Susan Bates, MD
Columbia University Medical Center
Grant: 2020 Pancreatic Cancer Action Network Translational Research Grant, extension funded by Kenneth D. Custance and Gladys C. Custance, honoring the memory of Martha 'Molly' Reed Woodroofe
Topic: Exploiting a metabolic vulnerability created by epigenetic therapy
Gregory Beatty, MD, PhD
University of Pennsylvania
Grant: 2017 Pancreatic Cancer Action Network Precision Medicine Targeted Grant, 2022 Grant Extension funded by Leslie Gaynor in memory of Phyllis Bolotin
Topic: Multiplex tissue-based assays and analytical tools for pancreatic cancer
Thomas Heineman, MD, PhD
Oncolytics Biotech, Inc.
Grant: 2023 Pancreatic Cancer Action Network Therapeutic Accelerator Award, supported in memory of Skip Viragh
Topic: Pelareorep + mFOLFIRINOX +/- atezolizumab for the treatment of 1L mPDAC
Dana-Farber Cancer Institute
Grantee
Andrew_Aguirre@dfci.harvard.edu
Sharon Alincastre
Novocure
salincastre@novocure.com
Brittany Allen-Petersen, PhD
Purdue University
Grantee
ballenpe@purdue.edu
Basil Bakir, MD, PhD
Columbia University
Grantee
bb3041@cumc.columbia.edu
Dafna Bar-Sagi, PhD
NYU Langone Health
PanCAN Scientific and Medical Advisory Board
Dafna.Bar-Sagi@nyulangone.org
Susan Bates, MD
Columbia University
Grantee
seb2227@cumc.columbia.edu
Gregory Beatty, MD, PhD
University of Pennsylvania
Grantee, PanCAN Scientific and Medical Advisory Board, Precision Promise
gregory.beatty@pennmedicine.upenn.edu
Jordan Berlin, MD
Vanderbilt University Medical Center
PanCAN Scientific and Medical Advisory Board
jordan.berlin@vumc.org
Jonathan Brody, PhD
Oregon Health & Science University
PanCAN Scientific and Medical Advisory Board
brodyj@ohsu.edu
Kirsten Bryant, PhD
University of North Carolina at Chapel Hill
Grantee
bryantkl@email.unc.edu
Ewa Carrier, MD
FibroGen
ecarrier@fibrogen.com
Rohit Chandwani, MD, PhD
Weill Cornell Medicine
Grantee
roc9045@med.cornell.edu
Suresh Chari, MD
MD Anderson Cancer Center
Grantee, PanCAN Scientific and Medical Advisory Board, PanCAN Early Detection Initiative
stchari@mdanderson.org
Yuan Chen, PhD
UC San Diego
Grantee
yuc020@health.ucsd.edu
Wansu Chen, PhD
Kaiser Permanente Southern California
Grantee, PanCAN Scientific and Medical Advisory Board, PanCAN Early Detection Initiative
wansu.chen@kp.org
Gabi Chiorean, MD
University of Washington/Fred Hutchinson Cancer Center
PanCAN Scientific and Medical Advisory Board, Precision Promise
gchiorea@outlook.com
Sheena Clift, PhD
Verastem Oncology
sclift@verastem.com
Guillaume Cognet, PhD
University of Chicago
Grantee cognetg@uchicago.edu
Howard Crawford, PhD
Henry Ford Health
PanCAN Scientific and Medical Advisory Board
hcrawfo1@hfhs.org
Jashodeep Datta, MD
University of Miami
Grantee, Precision Promise
jash.datta@med.miami.edu
Louis Denis, MD
Verastem Oncology
Grantee
LDenis@Verastem.com
Channing Der, PhD
University of North Carolina at Chapel Hill
Grantee, PanCAN Scientific and Medical Advisory Board Emeritus
cjder@med.unc.edu
Luis Francisco Diaz
OHSU Knight Cancer Institute
PanCAN Travel Scholar
diazlui@ohsu.edu
Julien Dilly, MSc
Dana-Farber Cancer Institute
Grantee
Julien_Dilly@DFCI.HARVARD.EDU
Efrat Dotan, MD
Fox Chase Cancer Center
PanCAN Scientific and Medical Advisory Board
efrat.dotan@fccc.edu
Stephanie Dougan, PhD
Dana-Farber Cancer Institute
Grantee, Precision Promise
stephanie_dougan@dfci.harvard.edu
José Enriquez
MD Anderson Cancer Center
PanCAN Travel Scholar
JSEnriquez@mdanderson.org
Ralph Francescone, PhD
Henry Ford Health
Grantee
rfrance3@hfhs.org
Will Freed-Pastor, MD, PhD
Dana-Farber Cancer Institute
Grantee
William_Freed-Pastor@DFCI.HARVARD.EDU
Tamer Garawin, MD
Ipsen
tamer.garawin@ipsen.com
University of Minnesota
Grantee
guptaarjun90@gmail.com
Tom Heineman, MD, PhD
Oncolytics Biotech
Grantee
theineman@oncolytics.ca
Andrew Hendifar, MD, MPH
Cedars-Sinai
PanCAN Scientific and Medical Advisory Board, Precision Promise
andrew.hendifar@cshs.org
Joseph Herman, MD, MSc
Northwell Health Cancer Institute
PanCAN Scientific and Medical Advisory Board
jherman1@northwell.edu
Manuel Hidalgo, MD, PhD
Weill Cornell Medicine
PanCAN Scientific and Medical Advisory Board, Precision Promise
Mah4006@med.cornell.edu
Colin Hill
Aitia
Colin@aitiabio.com
Sunil Hingorani, MD, PhD
University of Nebraska Medical Center
Grantee, PanCAN Scientific and Medical Advisory Board, Precision Promise
shingorani@unmc.edu
Aaron Hobbs, PhD
Medical University of South Carolina
Grantee
hobbsg@musc.edu
Tony Hollingsworth, PhD
University of Nebraska Medical Center
PanCAN Scientific and Medical Advisory Board
mahollin@unmc.edu
Peter Hosein, MD
University of Miami
PanCAN Scientific and Medical Advisory Board
phosein@miami.edu
Will Hwang, MD, PhD
Massachusetts General Hospital
Grantee
WHWANG1@mgh.harvard.edu
Aditi Jain, PhD
Thomas Jefferson University
Grantee
Aditi.Jain@jefferson.edu
Avinash Kambadakone-Ramesh, MD, MBBS
Massachusetts General Hospital
PanCAN Early Detection Initiative
AKAMBADAKONE@mgh.harvard.edu
Alison Klein, PhD
Johns Hopkins University
PanCAN Scientific and Medical Advisory Board
aklein1@jhmi.edu
Paul Kurywchak, PhD
Skipper Bio Med
Special Guest
paul@skipperbiomed.com
Ashley Laursen, PhD
Ipsen
ashley.laursen@ipsen.com
Andrew Lee, PharmD
AstraZeneca
andrew.lee4291@gmail.com
Fengzhi Li, PhD
Roswell Park Comprehensive Cancer Center
Grantee
fengzhi.li@roswellpark.org
Andrew Lowy, MD
UC San Diego
PanCAN Scientific and Medical Advisory Board, Precision Promise
Alowy@health.ucsd.edu
Chris Macdonald, PhD
Pancreatic Cancer UK
PanCAN Scientific Collaborator
Chris.Macdonald@pancreaticcancer.org.uk
Sanjana Mahapatra, PhD
Skipper Bio Med
Special Guest
sanjana@skipperbiomed.com
Anirban Maitra, MBBS
MD Anderson Cancer Center
PanCAN Early Detection Initiative, PanCAN Scientific and Medical Advisory Board Emeritus
amaitra@mdanderson.org
Mokenge Malafa, MD
Moffitt Cancer Center
PanCAN Scientific and Medical Advisory Board Emeritus
mokenge.malafa@moffitt.org
Meg Mandelson, PhD, MPH
Benaroya Research Institute
PanCAN Scientific and Medical Advisory Board Emeritus
mmandelson@benaroyaresearch.org
Ronald Matteotti, MD
Bristol Myers Squibb
ronald.matteotti@bms.com
Nipun Merchant, MD
University of Miami
PanCAN Scientific and Medical Advisory Board, Precision Promise
nmerchant@miami.edu
Janielle Maynard, PhD
Johns Hopkins University
Grantee
maynard@jhmi.edu
Simon Miller, MSc
FibroGen
smiller@fibrogen.com
Christine Mormont, PhD
Novocure
cmormont@novocure.com
John Morris IV, PhD
University of North Carolina at Chapel Hill
Grantee
jpmiv@email.unc.edu
Cedars-Sinai
PanCAN Scientific and Medical Advisory Board
nicholas.nissen@cshs.org
Marcus Noel, MD
Georgetown Lombardi Comprehensive Cancer Center
PanCAN Scientific and Medical Advisory Board
Marcus.S.Noel@gunet.georgetown.edu
Shannon Oda, PhD
University of Washington, Seattle Children's Research Institute
Grantee
Shannon.Oda@seattlechildrens.org
Kenneth Olive, PhD
Columbia University
Grantee
kpo2104@cumc.columbia.edu
Eileen O'Reilly, MD
Memorial Sloan Kettering Cancer Center
PanCAN Scientific and Medical Advisory Board, Precision Promise
oreillye@mskcc.org
Jon Pachter, PhD
Verastem Oncology
Grantee
jpachter@verastem.com
Shubham Pant, MD
MD Anderson Cancer Center
PanCAN Scientific and Medical Advisory Board, Precision Promise
SPant@mdanderson.org
Marina Pasca di Magliano, PhD
University of Michigan
Grantee, PanCAN Scientific and Medical Advisory Board
marinapa@umich.edu
Krushna Patra, PhD
University of Cincinnati
Grantee
patraka@ucmail.uc.edu
Vince Picozzi, MD
Virginia Mason
PanCAN Scientific and Medical Advisory Board, Precision Promise
vincent.picozzi@commonspirit.org
Michael Pishvaian, MD, PhD
Johns Hopkins University
PanCAN Scientific and Medical Advisory Board
mpishva1@jh.edu
Xiaoyang Qi, PhD
University of Cincinnati
Grantee
xiaoyang.qi@uc.edu
Mustafa Raoof, MD, MSc
City of Hope Comprehensive Cancer Center
Grantee
mraoof@coh.org
Nicolette Rodriguez, MD, MPH
Dana-Farber Cancer Institute
Grantee
njrodriguez@bwh.harvard.edu
Victoire Ruffino, PhD
Institut Curie
Grantee
victoire.ruffino@curie.fr
Maryam Safari, PhD
Columbia University
Special Guest
ms5244@cumc.columbia.edu
Jami Saloman, PhD
University of Pittsburgh
Grantee
jls354@pitt.edu
Rosie Sears, PhD
Oregon Health & Science University
PanCAN Scientific and Medical Advisory Board
searsr@ohsu.edu
Melissa Shackelford, MSc, MPH
Novocure
mshackelford@novocure.com
Sandra Shaw
Mirati Therapeutics
shaws@mirati.com
Rahul Shinde, PhD
The Wistar Institute
Grantee
rshinde@wistar.org
Dustin Srinivas, PhD
Skipper Bio Med
Special Guest
dustin@skipperbiomed.com
Shravya Srinivas Rao, MD, MBBS
Massachusetts General Hospital
PanCAN Early Detection Initiative
ssrinivasrao@mgh.harvard.edu
Sapna Syngal, MD, MPH
Dana-Farber Cancer Institute
Grantee, PanCAN Scientific and Medical Advisory Board
sapna_syngal@dfci.harvard.edu
Margaret Tempero, MD
UC San Francisco
PanCAN Scientific and Medical Advisory Board, Precision Promise
Margaret.tempero@ucsf.edu
Chinedu Ukaegbu, MBBS, MPH
Dana-Farber Cancer Institute
Special Guest
chinedu_ukaegbu@dfci.harvard.edu
Colin Weekes, MD, PhD
Massachusetts General Hospital
PanCAN Scientific and Medical Advisory Board
cdweekes@mgh.harvard.edu
Catherine Whittington, PhD
Worcester Polytechnic Institute
Grantee
cfwhittington@wpi.edu
Jen Jen Yeh, MD
University of North Carolina at Chapel Hill
PanCAN Scientific and Medical Advisory Board
jen_jen_yeh@med.unc.edu
THANK YOU
We're looking forward to seeing you at PanCAN Scientific Summit 2022 on September 12 & 13 in Boston, MA