PanCAN Scientific Summit 2022

September 12 & 13 | Boston

REGISTER TO ATTEND

TACKLING THE WORLD’S TOUGHEST CANCER – TOGETHER

To fight the world’s toughest cancer, PanCAN has built the Community for Progress, a robust and collaborative research community to tackle the disease from all angles. These scientists, clinicians, patients, industry partners and visionary donors drive groundbreaking scientific and clinical initiatives to improve outcomes for all patients with pancreatic cancer.


This year, we are excited to bring the PanCAN Community for Progress together in person for PanCAN Scientific Summit 2022, where you will have the opportunity to:


  • Meet our new PanCAN research grant recipients
  • Learn more about our top research initiatives
  • Hear from PanCAN’s young investigators as well as senior research grant recipients
  • Engage in discussions about emerging science in the field
  • Meet colleagues, collaborators, patient research advocates, and some rising stars in the field

When the Summit ends, we hope you stay in Boston to attend the American Association for Cancer Research (AACR) Special Conference: Pancreatic Cancer. PanCAN is proud to be a major sponsor of this conference and we hope to see you there after the Summit concludes.

PanCAN has a bold goal to drive the 5-year survival rate of pancreatic cancer to 20% by 2030. We can’t do it without you! Thank you for joining us as we keep pancreatic cancer research moving forward, together.


REGISTER TO ATTEND

*Attire: Business / Business Casual / Wear Your Purple!

Monday, September 12, 2022

5:30 p.m. — 6:30 p.m.

PanCAN Scientific and Medical Advisory Board Reception (closed, invite only)

6:30 p.m. — 10:00 p.m.

General Reception

Welcome Remarks

Julie Fleshman, JD, MBA, PanCAN President and CEO

Poster Session
2021 Class of Career Development Awards and Fellowships

Evaluation of Antitumor Immunity in Human Clinical Trials
Victoire Cardot-Ruffino, PhD, Dana-Farber Cancer Institute
Grant Funded by The Francois Wallace Monahan Fund in memory of Michael Insel


Preclinical Evaluation of Netrin-1 Antibody for Treatment of Pancreatic Cancer
Charline Ogier, PhD, Fox Chase Cancer Center
Grant funded by The Francois Wallace Monahan Fund in memory of Michael Insel


Hnf1b Defines an Epigenetic Ontology of Human Pancreatic Cancer
Rohit Chandwani, MD, PhD, Weill Cornell Medicine
Grant funded by The Jim & Shirley Young Family Foundation


Metabolic Link to Immunosuppressive Fibroblasts in Pancreatic Cancer
Ralph Francescone, PhD, Fox Chase Cancer Center
Grant funded in memory of Skip Viragh


Targeting BARD1 in Pancreatic Ductal Adenocarcinoma
Aditi Jain, PhD, Thomas Jefferson University


Dissecting Malignant Evolution Unleashed by p53 Inactivation in PDAC
John Morris IV, PhD, University of North Carolina at Chapel Hill
Grant funded in memory of Skip Viragh


Developing Engineered Proteins to Enhance Adoptive Cell Therapy of PDA
Shannon Oda, PhD, Seattle Children’s Research Institute
Grant funded by Linda E. Amuso in memory of Susan A. Lombardi


Fibrosis-mediated Transformation in Pancreatic Cancer Risk Factors In Vitro
Catherine Whittington, PhD, Worcester Polytechnic Institute


Tuesday, September 13, 2022

8:00 a.m. — 8:30 a.m.

Breakfast

8:30 a.m. — 8:35 a.m.

Community for Progress and 2022 Scientific Summit Overview

Margaret Tempero, MD, University of California, San Francisco Chair, PanCAN Scientific and Medical Advisory Board

8:35 a.m. — 8:55 a.m.

PanCAN State of the Union and Welcome 2022 Class of Grantees

Julie Fleshman, JD, MBA

8:55 a.m. — 9:50 a.m.

Early Detection

Session Facilitator: Lynn Matrisian, PhD, MBA, PanCAN Chief Science Officer

8:55 a.m. — 9:20 a.m.

PanCAN Early Detection Initiative

Suresh Chari, MD, MD Anderson Cancer Center Study PI

9:20 a.m. — 9:50 a.m.

Early Detection Research Project

Racial/ethnic Equity in GENetic Education, Risk Assessment and Testing (REGENERATE) Study

Sapna Syngal, MD, MPH, Dana-Farber Cancer Institute
Grant extension funded by Janssen Research & Development, LLC

Nicolette Juliana Rodriguez, MD, MPH, Brigham and Women’s Hospital
Grant funded by an anonymous donor

9:50 a.m. — 10:00 a.m.

Break

10:00 a.m. — 11:40 a.m.

Career Development Awards

10:00 a.m. — 10:20 a.m.

Microenvironment Induced Metabolic Requirements of Pancreatic Cancers
Alexander Muir, PhD, University of Chicago

10:20 a.m. — 10:40 a.m.

Duodenal Control of Pancreatic Ductal Adenocarcinoma
Daria Esterházy, PhD, University of Chicago

10:40 a.m. — 11:00 a.m.

CA 19-9 Promotes Pancreatitis and Pancreatic Cancer
Jan Lumibao, PhD, Salk Institute for Biological Studies (on behalf of Dannielle Engle, PhD)
Grant funded in memory of Skip Viragh

11:00 a.m. — 11:20 a.m.

Delineating Oncogenic Circuitries of GNAS Mutant Pancreatic Neoplasms
Krushna Patra, PhD, University of Cincinnati
Grant funded by Steven & Cheryl Kole and Harriet & Gerald Berner Family Charitable Fund

11:20 a.m. — 11:40 a.m.

Targeting Transcription-Replication Conflicts in Pancreatic Cancer
Mustafa Raoof, MD, FACS, Beckman Research Institute of the City of Hope
Grant funded in memory of Skip Viragh

11:40 a.m. — 12:00 p.m.

Research Acceleration Network Grant

Eliminating T Cell Barriers in Pancreatic Cancer Patients
Steven Leach, MD, Dartmouth College
Grant funded by Celgene Corporation

12:00 p.m. — 12:50 p.m.

Lunch

12:50 p.m. — 1:00 p.m.

Industry Member Interlude

1:00 p.m. — 2:00 p.m.

Translational Research Grants

1:00 p.m. — 1:20 p.m.

Therapeutic Induction of Tumor Selective Ferroptosis in Pancreatic Cancer
Kenneth Olive, PhD, Columbia University

1:20 p.m. — 1:40 p.m.

Proglumide and the Pancreatic Cancer Microenvironment
Jill Smith, MD, Georgetown University

1:40 p.m. — 2:00 p.m.

Investigating Netrin-1 as a New Therapeutic Target in Pancreatic Cancer
Darren Carpizo, MD, PhD, University of Rochester

2:00 p.m. — 2:10 p.m.

PanCAN SPARK Health Data Platform

Sudheer Doss, PhD, PanCAN Chief Business Officer
Kawther Abdilleh, PhD, PanCAN Associate Director, Health Data Analytics

2:10 p.m. — 2:50 p.m.

PanCAN Precision Promise

Session Facilitator: Diane Simeone, MD, NYU Langone Health Chair, Precision Promise Steering Committee

2:10 p.m. — 2:15 p.m.

Precision PromiseSM Update

Diane Simeone, MD

2:15 p.m. — 2:35 p.m.

Precision Promise Correlative Study

IL-1b in pancreatic cancer induces local and systemic immunosuppression: correlates from the Precision Promise safety run-in trial of canakinumab, spartalizumab, and gemcitabine/n(ab) paclitaxel
Stephanie Dougan, PhD, Dana-Farber Cancer Institute

2:35 p.m. — 2:55 p.m.

Precision Medicine Targeted Grant

Murine Clinical Trials for the Evaluation of High Priority Therapeutic Targets for Precision Promise
Sunil Hingorani, MD, PhD, University of Nebraska
Grant Extensions funded by 1440 foundation; Cheryl & Steve Kole, and Rudy Revak

2:55 p.m. — 3:15 p.m.

Therapeutic Accelerator Award

Phase 1/2 Trial of VS-6766 + Defactinib and GEM + Nab-P in metastatic PDAC
Louis Denis, MD, and Jonathan Pachter, PhD, Verastem Oncology, Inc.
Grant supported by the 1440 Foundation and the Gail V. Coleman-Kenneth M. Bruntel Research Fund

3:15 p.m. — 3:30 p.m.

Closing Remarks

Margaret Tempero, MD
Julie Fleshman, JD, MBA

LOCATION

Sheraton Boston Hotel

39 Dalton St., Boston, MA 02199


PARKING

More details to follow

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Suresh Chari, MD

MD Anderson Cancer Center

Affiliation: Early Detection Initiative, Study PI

Topic: Early Detection Initiative (EDI Update)

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Sapna Syngal, MD, MPH

Dana-Farber Cancer Institute

Grant: 2021 Pancreatic Cancer Action Network Research Project, 2022 Pancreatic Cancer Action Network Catalyst Award funded by Janssen Research & Development, LLC

Topic: Racial/ethnic Equity in Genetic Education, Risk Assessment and Testing (REGENERATE) Study

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Nicolette Juliana Rodriguez, MD, MPH

Brigham and Women’s Hospital

Grant: 2022 Pancreatic Cancer Action Network Catalyst Award Funded by an Anonymous Donor

Topic: Racial/ethnic Equity in Genetic Education, Risk Assessment and Testing (REGENERATE) Study

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Alexander Muir, PhD

University of Chicago

Grant: 2020 Pancreatic Cancer Action Network Career Development Award

Topic: “Microenvironment Induced Metabolic Requirements of Pancreatic Cancers”

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Daria Esterháazy, PhD

University of Chicago

Grant: 2020 Pancreatic Cancer Action Network Career Development Award

Topic: Duodenal Control of Pancreatic Ductal Adenocarcinoma

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Jan Lumibao, PhD (on behalf of Dannielle Engle, PhD)

Salk Institute for Biological Studies

Grant: 2019 Skip Viragh Pancreatic Cancer Action Network Career Development Award

Topic: CA 19-9 Promotes Pancreatitis and Pancreatic Cancer

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Krushna Patra, PhD

University of Cincinnati

Grant: 2020 Pancreatic Cancer Action Network Career Development Award, funded by Steven & Cheryl Kole and Harriet & Gerald Berner Family Charitable Fund

Topic: Delineating Oncogenic Circuitries of GNAS Mutant Pancreatic Neoplasms

presenter image

Mustafa Raoof, MD, FACS

Beckman Research Institute of the City of Hope

Grant: 2020 Pancreatic Cancer Action Network Career Development Award in memory of Skip Viragh

Topic: Targeting Transcription-Replication Conflicts in Pancreatic Cancer

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Steven Leach, MD

Dartmouth College

Grant: 2015 Celgene Corporation – Pancreatic Cancer Action Network – AACR Research Acceleration Network Grant

Topic: Eliminating T cell barriers in pancreatic cancer patientsr

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Kenneth Olive, PhD

Columbia University

Grant: 2020 Pancreatic Cancer Action Network Translational Research Grant

Topic: Therapeutic Induction of Tumor Selective Ferroptosis in Pancreatic Cancer

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Jill Smith, MD

Georgetown University

Grant: 2020 Pancreatic Cancer Action Network Translational Research Grant

Topic: Proglumide and the Pancreatic Cancer Microenvironment

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Darren Carpizo, MD, PhD

University of Rochester

Grant: 2018 Pancreatic Cancer Action Network Translational Research Grant

Topic: Investigating Netrin-1 as a New Therapeutic Target in Pancreatic Cancer

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Diane Simeone

MD, NYU Langone Health

Affiliation: Chair, Precision Promise Steering Committee

Topic: Precision PromiseSM Update

presenter image

Stephanie Dougan, PhD

Dana-Farber Cancer Institute

Topic: Precision Promise Correlative Study

presenter image

Sunil Hingorani, MD, PhD

University of Nebraska

Grant: 2017 Pancreatic Cancer Action Network Precision Medicine Targeted Grant 2021 Extension funded by Cheryl and Steve Kole, and Rudy Revak

Topic: Murine Clinical Trials for the Evaluation of High Priority Therapeutic Targets for Precision Promise

presenter image

Jonathan Pachter, PhD

Verastem Oncology

Grant: 2022 Pancreatic Cancer Action Network Therapeutic Accelerator Award supported by the 1440 Foundation, and the Gail V. Coleman-Kenneth M. Bruntel Research Fund

Topic: Phase 1/2 Trial of VS-6766 + Defactinib and GEM + Nab-P in metastatic PDAC

presenter image

Louis Denis, MD

Verastem Oncology

Grant: 2022 Pancreatic Cancer Action Network Therapeutic Accelerator Award supported by the 1440 Foundation, and the Gail V. Coleman-Kenneth M. Bruntel Research Fund

Topic: Phase 1/2 Trial of VS-6766 + Defactinib and GEM + Nab-P in metastatic PDAC

More details to follow

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