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Patients who receive treatment based on their biology can live longer.

PanCAN's Know Your Tumor service provides eligible patients with information about their tumor's biology through free tissue biomarker testing. Using this information, Know Your Tumor also gives patients and their healthcare team access to personalized treatment recommendations, including available clinical trials, based on tumor biology. This approach, which uses a patient's tumor or genetic makeup to guide treatment decisions, is known as precision medicine.

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Every pancreatic cancer patient is different. Patients who receive treatment based on their biology can live longer. The Pancreatic Cancer Action Network strongly recommends all pancreatic cancer patients get genetic testing for inherited mutations as soon as possible after diagnosis and biomarker testing of their tumor tissue to help determine the best treatment options.

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What is Precision Medicine for Pancreatic Cancer?

Precision medicine is treatment based on your biology. There are two different types of tests that can be done to learn more about your biology. One test is biomarker testing of tumor tissue and the other is genetic testing for inherited mutations.

Biomarker testing of tumor tissue reveals your tumor's biology, such as genes and proteins within the tumor. This is the type of testing that is provided through Know Your Tumor. Genetic testing for inherited mutations shows mutations (changes) you were born with.

The information gathered through both types of testing can help your doctor identify treatments based on your individual biology.

Patients should discuss both tests with their healthcare team. Both tests can be available through their treating institution. Biomarker testing is also available through PanCAN's Know Your Tumor precision medicine service.

What Is Biomarker Testing?

Biomarker testing of tumor tissue tells you about the biology of your tumor. It is also sometimes called molecular profiling, tumor testing or genomic testing. A tissue sample is collected through a biopsy and analyzed. It can show changes in the tumor's genes or proteins. Your doctor may be able to use this information to make treatment decisions based on your individual tumor biology.

What Is Genetic Testing for Inherited Mutations?

Genetic testing looks for inherited mutations. You may have been born with inherited mutations even if you don't have a family history of cancer.

The alterations to a person's DNA are the same throughout their whole body. So, this analysis is usually done on a blood or saliva sample.

Like knowing the changes in your tumor, knowing the changes present in all the cells in your body can also help you and your healthcare team make treatment decisions.

Although PanCAN does not offer comprehensive genetic testing, PanCAN strongly recommends all patients with pancreatic cancer get genetic testing for inherited mutations as soon as possible after diagnosis to help determine the best treatment options

Patients who receive treatment based on their biology can live longer.
All pancreatic cancer patients are different, and treatment that works well for one person may not work as well for someone else.
Many factors influence a person's response to treatment, including age, stage of diagnosis, your biology and the tumor's biology.
Knowing the alterations in your tumor or throughout your body can help you and your healthcare team select treatment options, including clinical trials, that are likely to work best for you. These treatments may not have been considered otherwise.
Precision medicine also benefits future patients. Researchers are studying precision medicine to discover new information about tumors and treatments that can help even more patients.

Who Should Consider Precision Medicine?

The Pancreatic Cancer Action Network strongly recommends that all pancreatic cancer patients get tumor biomarker testing and genetic testing for inherited mutations as soon as possible after diagnosis to help determine the best treatment options.

Your doctor may have done several tests on your tumor, so it is important to know if one of those tests was biomarker testing.

Ask your doctor if biomarker testing has been performed on your tumor and if they have used the results to make a treatment decision.
PanCAN Patient Services can help explain different types of pancreatic cancer testing.
If you've already had biomarker testing, PanCAN Patient Services can help you understand your results and give you information on treatment options, including clinical trials.

Pancreatic cancer patients should get tumor biomarker testing and genetic testing as early as possible after diagnosis. However, testing can happen at any time.

Because tissue is needed to perform tumor biomarker testing, a doctor must determine the best way to collect a sample. If you are having your tumor surgically removed, tissue from the surgery may be used. In most other cases, a specific type of biopsy, called a core biopsy, is needed.

If you are currently on treatment, you can get testing at the same time so that you have the information if you need to make a future treatment decision.

Your doctor or hospital may offer testing, especially if you are seen at a high-volume center. If you can't get testing through your doctor or hospital, contact PanCAN Patient Services to discuss other options. Patient Services can also offer resources to help you talk to your doctor about testing.

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